Papers

1.     Goldfarb AM*, Sasi NK*, Dilgen TC, Cai SW, Myler LR, de Lange T. Tetrameric TRF2 forms t-loop to protect telomeres from ATM signaling and cNHEJ. (2024). BioRxiv.

2.     Kinzig CG, Zakusilo G, Takai K, Myler LR, de Lange T. ATR blocks telomerase from converting DNA breaks into telomeres. (2024). Science.

3.     Myler LR*, Toia B*, Vaughan CK, Sonmez C, Takai K, Matei AM, Wu P, Paull TT, de Lange T#, Lottersberger F#. DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading end telomeres. (2023). Nature Structural and Molecular Biology.

·       See also News and Views in NSMB: https://www.nature.com/articles/s41594-023-01077-6

4.     Myler LR*, Kinzig CG*, Sasi NK, Zakusilo G, Cai SW, de Lange T. The evolution of metazoan shelterin. (2021). Genes and Development.

·       Recommended by Faculty Opinions: https://facultyopinions.com/article/741150958

5.     Deshpande RA, Myler LR, Soniat MM, Makharashvili N, Lee L, Lees-Miller SP, Finkelstein IJ, Paull TT. DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP. (2020). Science Advances.

6.     Caron M-C*, Sharma A*, O’Sullivan J, Myler LR, Feirrera MT, Rodrigue A, Coulombe Y, Ethier C, Gagné J-P, Langelier M-F, Pascal JM, Finkelstein IJ, Hendzel M, Poirier GG, Masson, J-Y. Poly(ADP-ribose) polymerase 1 antagonizes DNA resection at double-strand breaks. (2019). Nature Communications.

7.     Soniat MM, Myler LR, Kuo H-C, Paull TT, Finkelstein IJ. RPA phosphorylation inhibits DNA resection. (2019). Molecular Cell.

8.     Soniat MM, Myler LR, Finkelstein IJ. (2019). Assembling the Human Resectosome One Molecule at a Time. Methods in Molecular Biology.

9.     Myler LR, Soniat MM, Zhang X, Deshpande RA, Paull TT, Finkelstein IJ. Purification and biophysical characterization of the Mre11-Rad50-Nbs1 complex. (2019). Methods in Molecular Biology.

10.  Dillard KE*, Brown MW*, Johnson NV, Xiao Y, Dolan A, Hernandez E, Dahlhauser SD, Kim Y, Myler LR, Anslyn EV, Ke A, Finkelstein IJ. (2018). Assembly and translocation of a CRISPR-Cas primed acquisition complex. Cell.

11.  Johnson TE, Lee J-H, Myler LR, Zhou Y, Mosley TJ, Yang S-H, the Bio-Bricks for Molecular Machines FRI stream, Uprety N, Kim J, Paull TT. (2018). Homeodomain proteins directly regulate ATM kinase activity. Cell Reports.

12.  Myler LR*, Gallardo IF*, Soniat MM, Deshpande RA, Gonzalez XB, Kim Y, Paull TT, Finkelstein IJ. (2017). Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair. Molecular Cell.

·       Recommended by Faculty Opinions: https://facultyopinions.com/article/730591997

13.  Myler LR, Finkelstein IJ. Eukaryotic resectosomes: A single-molecule perspective. (2017). Progress in Biophysics and Molecular Biology.

14.  Soniat MM, Myler LR, Schaub JM, Kim Y, Gallardo IF, Finkelstein IJ. (2017). Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination. Methods Enzymology.

15.  Myler LR*, Gallardo IF*, Zhou Y, Gong F, Yang S-H, Wold MS, Miller KM, Paull TT#, Finkelstein IJ#. Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins. (2016) PNAS.

16.  Lee J-H*, Guo Z*, Myler LR, Zheng S, Paull TT. (2014). Direct activation of ATM by resveratrol under oxidizing conditions. PLoS ONE.

*These authors contributed equally. #Co-corresponding authors.